Applications of pericyclic reactions||Biosynthesis of Vitamin D-D2-D3|ergocalciferol-cholecalciferol
Assalam o Alaikum
in this lecture i am going to discuss Applications of pericyclic reactions OR Biosynthesis of Vitamin D-D2-D3. vitamin D2 is known as ergocalciferol and vitamin D3 is known as cholecalciferol. we synthesize cholecalciferol and ergocalciferol from their precurser. the precurser used are Ergosterol and 7-dehydrocholesterol.This lecture is delivered in Urdu ,Hindi and English.
Vitamin D is the general name for two related compounds called cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2). These two compounds differ in the identity of the side chain, R group.Vitamin D serves an important function in that it increases the body’s ability to metabolize the calcium present in the foods we eat. Calcium is essential because it is used in the formation of bones and teeth. A deficiency of vitamin D can cause the childhood disease called rickets, which is characterized by abnormal bone growth. Although most food does not contain substantial amounts of vitamin D, some food sources do contain the precursors that the body needs in order to synthesize vitamin D. Ergosterol is present in many vegetables, and 7-dehydrocholesterol is present in fish and dairy products.When the skin is exposed to sunlight, these precursors, located just beneath the skin, are converted into ergocalciferol and cholecalciferol respectively. For this reason, vitamin D is commonly called the “sunshine vitamin.” The precursors are converted into vitamin D via two successive pericyclic reactions.The first step is an electrocyclic ring-opening reaction, and the second step is a [1,7] sigmatropic rearrangement. This sequence of steps not only occurs in our bodies but is also utilized commercially to enrich milk with vitamin D3.
All milk sold in the United States is irradiated with UV light, which converts the 7-dehydrocholesterol present in the milk into vitamin D3.
Main contents that i have cover in this lecture are following:-
1) Applications of pericyclic reactions
2) Biosynthesis of Vitamin D &D2 &D3 by pericyclic reactions
3)Biosynthesis of ergocalciferol (vitamin D2) from Ergosterol .
4) Biosynthesis of cholecalciferol (vitamin D3) from 7-dehydrocholesterol
5)importance of pericyclic reactions
6) advantages of pericyclic reactions
7) pericyclic reactions importance in daily life.
8) structure of ergocalciferol (vitamin D2)
9) structure of cholecalciferol (vitamin D3
10)structure of Ergosterol
11)structure of 7-dehydrocholesterol
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